High D Allele Frequency of ACE I/D Gene Polymorphism in Familial Hypertension in Javanese Indonesian

Abstract

Family studies demonstrated the contribution of genetic factor to the development of essential hypertension. While the familial component of blood pressure(BP) is well described, the risk of hypertension developing as a result of family history has not been well quantified . The heritage portion of blood pressure is estimated to range between 35% and 65% . Genetic polymorphisms are related to hypertension. Genes coded in the components of renin-angiotensin-aldosteron system(RAAS) are crucial in the pathogenesis of essensial hypertension via the blood pressure management. Epidemiological studies have suggested that nucleotide sequence variations of genes such as angiotensinogen(AGT), renin(REN), angiotensin-converting enzyme (ACE), angiotensin II receptor type I(AT─1R) and aldosterone synthase(CYP11B2) are associated with the risk of essensial hypertension . The ACE insertion/deletion(I/D) gene polymorphism and a predisposition to hypertension have been shown in many studies. More than 100 polyOriginal Articles