ALTERAÇÕES DA RESPOSTA IMUNE EM PACIENTES COM OBESIDADE

Tecnologias aplicadas nas ciências da saúde (Vol. 2) Pub Date : 1900-01-01 DOI:10.34119/bjhrv3n4-350

Andrelia Correa da Silva, Denise Neves Ladeia, Diana Neves Ladeia, E. Zanotti, G. Gazzoni, Gabriela Neto Rodrigues, Loan Langowski, Luis Eduardo Gonçalves Schmidt, Marina Laís Scarton

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Abstract

Objective: To carry out a narrative review on changes in the immune response in patients with obesity. This review presents an understanding of the impact that adiposity has on the function of the immune system. Methodology: Searches were performed in the Medical Literature Analysis and Retrievel System Online database (MEDLINE / Pubmed) using the descriptors Obesity; Immune response; Immune System Diseases and Disturb. Results / Discussion: It was evidenced through this study that obesity is related to several immunological changes at the cellular level. Excess fatty tissue is involved in changes in serum levels of interleukins that work to resolve inflammation, such as IL-33, in addition to an imbalance between type 1 and type 2 cytokines. Obesity was also associated with higher chances of development and therapeutic failure in rheumatic diseases, as well as changes in the concentration of type I Brazilian Journal of health Review Braz. J. Hea. Rev., Curitiba, v. 3, n. 4, p. 10945-10960 jul./aug.. 2020. ISSN 2595-6825 10947 interferon, gamma interferon, leptin and other pro-inflammatory cytokines. In addition, this pathology was associated with response and high viral load in respiratory virus infections. Conclusion: The elevated lipid profile has a considerable impact on the immune system, triggering metabolic and inflammatory disorders. These changes are related to the progression of chronic disease, changes in immunity and vaccine efficacy.

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肥胖患者免疫反应的变化

目的:对肥胖患者免疫反应的变化进行综述。这篇综述提出了对肥胖对免疫系统功能影响的理解。方法:在医学文献分析和检索系统在线数据库(MEDLINE / Pubmed)中使用描述词“肥胖”进行检索;免疫反应;免疫系统疾病和干扰。结果/讨论:本研究证明肥胖与细胞水平的多种免疫变化有关。除了1型和2型细胞因子之间的不平衡外，多余的脂肪组织还参与了血清中消除炎症的白细胞介素水平的变化，比如IL-33。肥胖还与风湿性疾病的发展和治疗失败的更高机会以及I型血浓度的变化有关。j .头脑。Rev.， Curitiba, v. 3, n. 4, p. 10945-10960 7 / 8…2020. 干扰素，γ干扰素，瘦素和其他促炎细胞因子。此外，这种病理与呼吸道病毒感染的反应和高病毒载量有关。结论:血脂升高对免疫系统有相当大的影响，引发代谢和炎症紊乱。这些变化与慢性疾病的进展、免疫力的变化和疫苗效力有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tecnologias aplicadas nas ciências da saúde (Vol. 2)

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