Biomarker responses of cardiac oxidative stress to high intensity interval training in rats

Motriz: Revista de Educação Física Pub Date : 1900-01-01 DOI:10.1590/S1980-65742021021420

Lúcio Marques Vieira-Souza, J. L. Santos, A. C. Marçal, F. Voltarelli, F. Aidar, R. Miguel-dos-Santos, Rôas de Araújo Costa, D. Matos, S. L. Santos, S. S. Araújo

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Abstract

Aim: The present study aimed to verify the cardiac oxidative stress biomarker responses to high-intensity interval training (HIIT) in rats. Methods: Sixteen male Wistar rats weighing 250 to 300 g were equally divided into two groups (8 animals/group): sedentary control (SC) and trained group (HIIT). The exercise protocol consisted of highintensity swimming (14% of body weight, 20 s of activity with 10 s of pause performed 14 times) which was performed for 12 consecutive days. Results: The cardiac tissue concentrations of malondialdehyde and carbonylated proteins showed no significant changes; on the other hand, hydroperoxide levels were higher in the HIIT group than in the SC group. The activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes and the levels of reduced glutathione and sulfhydryl remained unchanged. Conclusion: It is possible to conclude that short-term high-intensity interval training induces changes in the cardiac oxidative stress biomarker but with no effect on the antioxidant

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大鼠心脏氧化应激对高强度间歇训练的生物标志物反应

目的:本研究旨在验证大鼠心脏氧化应激生物标志物对高强度间歇训练(HIIT)的反应。方法:16只体重250 ~ 300 g的雄性Wistar大鼠平均分为2组(8只/组):久坐对照组(SC)和训练组(HIIT)。运动方案包括高强度游泳(占体重的14%，活动20秒，暂停10秒，共14次)，连续12天。结果:心肌组织丙二醛和羰基化蛋白浓度无明显变化;另一方面，HIIT组的过氧化氢水平高于SC组。超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性以及还原性谷胱甘肽和巯基的水平保持不变。结论:短期高强度间歇训练可能会引起心脏氧化应激生物标志物的变化，但对抗氧化剂没有影响

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Motriz: Revista de Educação Física

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