PREVALENCE, DISTRIBUTION AND DETERMINANTS OF ESCHERICHIA COLI RESISTANCE TO CEFTRIAXONE IN ADULT INDOOR UTI POPULATION OF DISTRICT PESHAWAR, PAKISTAN

Abstract

Background: Escherichia coliresistance to ceftriaxone in UTIs is an emerging health problem.Our objectives were to determine prevalence, distribution and determinants of E. coliresistance to ceftriaxone in adult indoor UTI population of District Peshawar, Pakistan. Materials & Methods:This cross-sectional study was conducted in Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan from 1st January 2017 to 30th June 2017. 380 UTIs cases were selected from population at riskconsecutively.Sex and age groups were demographic, while presence of E. coli resistance to ceftriaxone was research variable. All variables were nominal.Prevalenceand distribution were analyzed by count, percentage and confidence intervals for proportion for population. Hypotheses for distribution were substantiated by chi-square goodness-of-fit and of association by chi-square test of association. Results: Out of 380 patients with UTI, 136 (35.80%) were men,244(64.20%) women, 262 (68.95%) in age group 18-45 years and 118 (31.05%) in age group 46-65 years. Frequency/ prevalence of E. coli resistance was 287/380 (75.53%, 95%CI 71.20-79.85). Out of 287 patients with E. coli resistance to ceftriaxone, 101 (26.58%) were men and 186 (48.95%) women, 198 (52.11%) in age group 18-45 years and 89 (23.42%) in age group 46-65 years. Our prevalence of E. coli resistance to ceftriaxone was higher than expected (p<.00001), our distribution by sex(p<.00125) and age groups (p<.00001) were different than expected. Presence of E. coli resistance to ceftriaxone was not associated to sex (p=.669333) and age groups (p=.975097). Conclusion:Prevalence of E. coli resistance to ceftriaxone in adult UTI population of District Peshawar, Pakistan was alarmingly high 75.53%. Prevalence was more in women than men and more in younger age group (18-45 years) than older age group (46-60 years) population.Overall prevalence of E. coli resistance to ceftriaxone was higher than expected. Distribution by sex showed higher prevalence than expected in men and lower than expected in women, and higher than expected in younger age group and lower than expected in older age group. Presence of E. coli resistance to ceftriaxone was not associated to sex and age groups respectively in adult UTI population of District Peshawar, Pakistan.