Impact of time-of-flight image reconstruction in PET parametric imaging

F. Kotasidis, A. Mehranian, H. Zaidi
{"title":"Impact of time-of-flight image reconstruction in PET parametric imaging","authors":"F. Kotasidis, A. Mehranian, H. Zaidi","doi":"10.1109/NSSMIC.2015.7582177","DOIUrl":null,"url":null,"abstract":"Kinetic parameter estimation in dynamic PET imaging requires reconstruction of multiple time frames. Due to the limited counting statistics and reduced signal-to-noise ratio (SNR) in each frame, parametric maps suffer from reduced accuracy and precision. Therefore image reconstruction strategies improving upon the SNR are particularly important in the context of parametric imaging. Time of flight image reconstruction has been shown to improve the SNR and increase the effective sensitivity. However so far the benefit of TOF has only been demonstrated in static imaging applications with potentially substantial benefits when used in dynamic pharmacokinetic imaging applications. Using traditional dynamic 3D as well as direct 4D image reconstruction algorithms we evaluate the benefit of TOF on kinetic parameter estimation using various TOF resolutions, kinetic models and count levels. Initial data suggest that both bias and variance in the kinetic parameters are reduced, with improvements depending on the kinetic model and becoming more significant at increased TOF resolutions. Incorporating TOF within direct 4D image reconstruction and combining the respecting SNR gains results in substantial improvements in parametric maps compared to traditional post reconstruction kinetic analysis.","PeriodicalId":106811,"journal":{"name":"2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","volume":"581 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2015 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/NSSMIC.2015.7582177","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Kinetic parameter estimation in dynamic PET imaging requires reconstruction of multiple time frames. Due to the limited counting statistics and reduced signal-to-noise ratio (SNR) in each frame, parametric maps suffer from reduced accuracy and precision. Therefore image reconstruction strategies improving upon the SNR are particularly important in the context of parametric imaging. Time of flight image reconstruction has been shown to improve the SNR and increase the effective sensitivity. However so far the benefit of TOF has only been demonstrated in static imaging applications with potentially substantial benefits when used in dynamic pharmacokinetic imaging applications. Using traditional dynamic 3D as well as direct 4D image reconstruction algorithms we evaluate the benefit of TOF on kinetic parameter estimation using various TOF resolutions, kinetic models and count levels. Initial data suggest that both bias and variance in the kinetic parameters are reduced, with improvements depending on the kinetic model and becoming more significant at increased TOF resolutions. Incorporating TOF within direct 4D image reconstruction and combining the respecting SNR gains results in substantial improvements in parametric maps compared to traditional post reconstruction kinetic analysis.
飞行时间图像重构对PET参数成像的影响
动态PET成像中的动力学参数估计需要重建多个时间帧。由于有限的计数统计和每帧的信噪比(SNR)降低,参数映射的准确性和精度降低。因此,在参数化成像的背景下,提高信噪比的图像重建策略尤为重要。飞行时间图像重建可以提高信噪比,提高有效灵敏度。然而,到目前为止,TOF的益处仅在静态成像应用中得到证实,而在动态药代动力学成像应用中则有潜在的实质性益处。使用传统的动态3D和直接4D图像重建算法,我们使用不同的TOF分辨率、动力学模型和计数水平来评估TOF在动力学参数估计上的优势。初始数据表明,动力学参数的偏差和方差都降低了,根据动力学模型的不同而有所改善,并且随着TOF分辨率的增加而变得更加显著。与传统的重建后动力学分析相比,在直接4D图像重建中结合TOF并结合相应的信噪比增益,可以显著改善参数图。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信