Effect of Total Parenteral Nutrition Therapy in Palliative Gastrojejunostomy Status Patients

Abstract

Purpose: Gastric outlet obstruction (GOO) is a common problem associated with advanced malignancies of the upper gastrointestinal tract. Adverse events, such as malnutrition, can affect the quality of life, and gastrojejunostomy can be performed for palliative care. This study evaluated effects of total parenteral nutrition (TPN) therapy in post-operation state patients who underwent a palliative gastrojejunostomy (PGJ). Materials and Methods: Between January 2011 and June 2015, a total of 65 patients underwent PGJ at Soonchunhyang University Cheonan Hospital and all consecutive patients were included in this retrospective study. All patients were divided into the preoperative TPN group and non-TPN group. A nutritional status assessment included the body weight (BW), body mass index (BMI), CRP level, serum albumin, serum total protein, hemoglobin, and total lymphocyte count (TLC). Results: Thirty-one patients did not receive the TPN treatment, and 34 patients received the TPN treatment before surgery. Significant differences between preoperative and postoperative BW, BMI, CRP level, serum albumin, serum total protein, hemoglobin, and TLC were observed in the non-TPN group. On the other hand, there was no significant difference between the preoperative BW, BMI, TLC and postoperative BW, BMI, TLC in the TPN group (p=0.914, p=0.873, p=0.319). Conclusion: These results suggest that preoperative TPN therapy can improve the nutritional status in patients who underwent PGJ. (Surg Metab Nutr 2018;9:26-30)