Prognostic Value of Tumour Size in Colon Cancer – Smaller is Better?

The American Surgeon™ Pub Date : 2021-06-09 DOI:10.21203/RS.3.RS-566870/V1

Siyi Lu, Bingyan Wang, Zhenzhen Liu, Fei Li, Yongqu Lu, Yan Meng, Junwei Wang, Hao Wang, Limei Guo, Xin Zhou, W. Fu

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Abstract

Background: The prognostic value of tumour size in colon cancer remains controversial. This study aimed to reveal the correlation between tumour size and prognosis of colon cancer.Methods: A total of 498 patients with colon cancer were included in this study. The correlation of tumour size with prognosis, mismatch repair status and other clinicopathological characteristics as well as tumour microenvironment was analysed.Results: For stage IIA microsatellite stable (MSS) colon cancer, tumours sized <3.5 cm and ≥5 cm were associated with a poorer disease free survival (DFS) compared with tumours sized between 3.5 and 5 cm (p=0.002). Small tumour size (HR=5.098, p=0.001) and large tumour size (HR=2.749, p=0.029) were found to be independent prognostic factors for stage IIA MSS colon cancer. Moreover, high expression of transgelin (TAGLN), a marker of cancer-associated fibroblasts (CAFs), was found to be an independent prognostic factor for poorer DFS (HR=9.651, p=0.009), which was also associated with smaller tumour size (p=0.027).Conclusion: Small (<3.5 cm) and large (≥5 cm) tumour sizes are associated with decreased DFS in stage IIA MSS colon cancer. Enrichment of TAGLN+ CAFs is associated with decreased DFS and small tumour size.

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肿瘤大小对结肠癌的预后价值-越小越好?

背景:肿瘤大小对结肠癌的预后价值仍有争议。本研究旨在揭示肿瘤大小与结肠癌预后的关系。方法:本研究共纳入498例结肠癌患者。分析肿瘤大小与预后、错配修复状态等临床病理特征及肿瘤微环境的相关性。结果:对于IIA期微卫星稳定型(MSS)结肠癌，肿瘤大小<3.5 cm和≥5 cm与肿瘤大小在3.5 ~ 5 cm之间的较差的无病生存(DFS)相关(p=0.002)。小肿瘤大小(HR=5.098, p=0.001)和大肿瘤大小(HR=2.749, p=0.029)是IIA期MSS结肠癌的独立预后因素。此外，肿瘤相关成纤维细胞(CAFs)的标志物transgelin (TAGLN)的高表达被发现是较差DFS的独立预后因素(HR=9.651, p=0.009)，这也与较小的肿瘤大小相关(p=0.027)。结论:小(<3.5 cm)和大(≥5 cm)肿瘤大小与IIA期MSS结肠癌DFS降低相关。TAGLN+ CAFs的富集与降低DFS和减小肿瘤大小有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The American Surgeon™

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