Influence of Artocarpus Altilis Fruit Extract on Cancer Cell

S. Ganeson, Muhammad Mahadi bin Abdul Jamil, R. Ambar, R. A. Wahab
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引用次数: 1

Abstract

Conventional chemopreventive agents causes adverse side effects in cancer patients. Thus, this study focuses on the effects of natural plant extract against cancer cell as a way to reduce or detrimental effects of orthodox drugs. The present study emphasizes on anti-cancer potentiality of Artocarpus altilis fruit extract against cervical cancer cell. Cervical cancer cell treated with methanol extract of artocarpus altilis fruit with the concentration varied from 10µg/ml, 20µg/ml, 30µg/ml, 40µg/ml and 50µg/ml. Treated and untreated (cells without treatment) cell proliferation and half maximal inhibitory concentration IC50 measured after 72 hours of incubation. Cells without treatment, 10µg/ml, 20µg/ml, 30µg/ml, 40µg/ml and 50 µg/ml of extract concentration showed 1.3, 0.98, 0.72, 0.65, 0.51, and 0.3 of cell proliferation factor accordingly with 40µg/ml of IC50 value. The result shows that artocarpus altilis is capable in opposing cervical cancer cell proliferation or growth as the proliferation factor decreases with the increasing dose of extract concentration which can be attributed to the presence of bioactive compound in Artocarpus altilis.
山茱萸果实提取物对癌细胞的影响
传统的化学预防药物会对癌症患者产生不良的副作用。因此,本研究的重点是天然植物提取物对癌细胞的作用,以减少传统药物的有害影响。本研究着重探讨了高鼻梁果提取物对宫颈癌细胞的抗癌作用。用10µg/ml、20µg/ml、30µg/ml、40µg/ml、50µg/ml的高罗汉果甲醇提取物处理宫颈癌细胞。处理和未处理(未处理的细胞)的细胞增殖和一半最大抑制浓度IC50孵育72小时后测定。未处理细胞,10µg/ml、20µg/ml、30µg/ml、40µg/ml、50µg/ml提取物浓度分别为细胞增殖因子1.3、0.98、0.72、0.65、0.51、0.3,IC50值为40µg/ml。结果表明,随着提取物浓度的增加,其增殖因子降低,具有抑制宫颈癌细胞增殖或生长的作用,这可能是由于其中含有生物活性化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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