Mitral Anular Calcification: An Age-Stratified Case-Control Study

Abstract

Age-adjusted oods ratios, 95% confidence limits, χ 2 values, and power to detect relative risks≥1.5 were used to compare the features of 371 patients with MAC (cases) to 672 age-stratified patients without MAC (controls). The results show a strong association between MAC and chronic renal insufficiency (odds ratio 2.7; 95% confidence limits 1.83 and 3.99; χ 2 24.8; p>0.001). Disproportionately high odds ratios for MAC and chronic renal insufficiency were found for ages 40-49 years (odds ratio 24.00) and 50-59 years (odds ratio 13.80). No association was found between MAC and ischemic cerebral vascular accidents (odds ratio 0.93; 95% confidence limits 0.67 and 1.38; power 0.73) or transient ischemic attacks (odds ratio 0.76; 95% confidence limits 0.42 and 1.38; power 0.76). Similarly, no associations were found between MAC and electrocardiographic diagnosis of myocardial infarction (odds ratio 0.85; 95% confidence limits 0.62 and 1.16; power 0.75), echocardiographic evidence for regional wall motion abnormality (odds ratio 0.83; 95% confidence limits 0.57 and 1.20; power 0.81), or the clinical diagnosis of atherosclerotic peripheral vascular disease (odds ratio 1.40; 95% confidence limits 0.98 and 2.00; power 0.73)