Serum ferritin assay.

C P Alfrey
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引用次数: 36

Abstract

Ferritin is an iron storage protein of high-molecular weight which is primarily present in the liver, spleen, and bone marrow. A very sensitive immunoradiometric assay has been developed which permits determination of serum concentrations in normal persons and in patients with a variety of different disorders. In normal subjects, the serum ferritin concentration correlates very well with total body iron stores as measured by phlebotomy. The serum ferritin concentration is reduced in patients with iron-deficient anemia and is significantly higher in patients who are anemic for other reasons. Subject areas discussed in this review include the details of the immunoradiometric procedure, the sensitivity and accuracy of the assay, factors influencing the assay, values characteristic of a variety of clinical disorders, and the utility of the assay in clinical medicine and public health.

血清铁蛋白测定。
铁蛋白是一种高分子量的储铁蛋白,主要存在于肝脏、脾脏和骨髓中。一种非常灵敏的免疫放射测定法已经开发出来,它可以测定正常人和各种不同疾病患者的血清浓度。在正常受试者中,血清铁蛋白浓度与静脉切开术测量的全身铁储量密切相关。缺铁性贫血患者血清铁蛋白浓度降低,而因其他原因贫血的患者血清铁蛋白浓度明显升高。本综述讨论的主题领域包括免疫放射测量程序的细节、测定的敏感性和准确性、影响测定的因素、各种临床疾病的特征值以及测定在临床医学和公共卫生中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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