Newer aspects of pernicious anemia.

L Kass
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引用次数: 1

Abstract

Although readily treatable with vitamin B12, pernicious anemia continues to captivate investigative endeavors of those interested in the pathophysiology and pathogenesis of this disorder. Notable advances have been made in understanding properties of intrinsic factor, vitamin B12-binding proteins, structure and de novo synthesis of vitamin B12, mechanism of action of vitamin B12-dependent enzymes in man, and metabolic consequences of reduced activities of these enzymes in pernicious anemia. Similarly, newer morphological observations have given information regarding pathogenesis of some of the cytological abnormalities found in megaloblasts, and recent cytochemical studies have shed light on abnormalities of nuclear and cytoplasmic constituents in vitamin B12-deficient cells. Both cellular and humoral factors may contribute to immune-mediated processes in pernicious anemia, although as yet, it has not been established with certainty that pernicious anemia is an autoimmune disorder. As we look ahead, it will be important to define the process or processes responsible for atrophic gastritis, which is the pathophysiological basis of pernicious anemia. Likewise, advances in biophysics used in the study of cell membranes, cell surface phenomena, and metallic ion transport may find applicability in the study of pernicious anemia and perhaps provide further insights into metabolic abnormalities responsible for the development of megaloblastosis.

恶性贫血的新方面。
虽然很容易用维生素B12治疗,恶性贫血仍然吸引着那些对这种疾病的病理生理学和发病机制感兴趣的人的调查努力。在对维生素B12的内在因子、维生素B12结合蛋白的性质、维生素B12的结构和新生合成、人体内维生素B12依赖酶的作用机制以及这些酶活性降低在恶性贫血中的代谢后果的认识方面取得了显著进展。同样,新的形态学观察已经提供了关于巨幼细胞中发现的一些细胞学异常的发病机制的信息,最近的细胞化学研究已经阐明了维生素b12缺乏细胞的核和细胞质成分的异常。细胞和体液因素都可能参与恶性贫血的免疫介导过程,尽管到目前为止,还没有确定恶性贫血是一种自身免疫性疾病。当我们展望未来时,重要的是确定萎缩性胃炎的过程或过程,这是恶性贫血的病理生理基础。同样,用于研究细胞膜、细胞表面现象和金属离子运输的生物物理学的进展可能会在恶性贫血的研究中找到适用性,并可能为研究巨幼细胞增生的代谢异常提供进一步的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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