13C Solid State Nuclear Magnetic Resonance as a Tool for Studying Polymorphism in Pharmaceuticals

Abstract

Mini Review NMR is one of the most versatile techniques for structural characterization. In addition, NMR is important for the study of organic and inorganic compounds, both for structural determination and for the use of samples, bonding types and geometry, as well as for analytical studies and their applications in a wide range of areas, including drug studies, such as pure IFA or pharmaceutical formulations and excipients. All types of solid material can be studied by NMR, including crystals and powders, amorphous materials such as glass and rubber, superconductors and metals [1]. The Hamiltonian that describes the interactions present in a sample containing nuclear spin nuclei (I), consists of a sum of Hamiltonians related to the magnetic and electrical properties of the sample being analyzed [2], as shown EQUATION 1: