Neoadjuvant Radiotherapy of Early-Stage and Locally Advanced Breast Cancer: Review of the Literature

Abstract

Breast cancer is the most frequently diagnosed cancer type among women worldwide. The treatment of breast cancer is multimodal and the current standard approach is surgery followed by adjuvant radiotherapy (RT) based on prognostic scores. Neoadjuvant chemotherapy and RT delivered in advance of surgery are used in some early stage and locally advanced cases, may offer an advantage over adjuvant therapy related to the potential benefits in the pathologic response and survival outcomes based the hypothesis of Abscopal effect.