Automatic Detection System to Identify Invasive Ductal Carcinoma by Predicting Bloom Richardson Grading from Histopathological Images

Abstract

Abstract: After skin cancer, the most common type of cancer is breast cancer among the world population. Breast cancer is the leading cause of cancer-induced mortality among women. Breast cancer is frequently diagnosed by using biopsies in which tissue is removed from the breast and studied under a microscope. The results of these biopsies are based on the qualifications and experience of the pathologist who diagnoses the abnormal cell under the microscope. With the emergence of advancements in the fields of image processing and artificial intelligence, there is an area of interest in developing a deep learning model to improve and enhance the quality and accuracy of breast cancer diagnosis. This study proposed a deep learning model that automatically analyses the multiclass classification of hematoxylin and eosin-stained histological images of invasive ductal carcinoma (IDC) by discriminating the IDC into grades such as G-1, G-2, and G-3. The methodology is focused on a deep learning model to detect grades of invasive ductal carcinoma by adopting the Sequential Convolutional Neural Network Two-Dimensional (CNN2D). We used DataBiox, a public dataset taken from an internet source consisting of 922 images. We evaluate the result of multiclass classification by dividing 80% and 20% of the dataset into training and testing data, respectively. As a result of the training and testing of the pre-trained CNN model, sequential CNN yields the accuracy of the model of 92.81%. Our model accurately classifies a multi-class classification of histological images of grades of breast cancer, specifically IDC. It is ready to be tested with a more diverse and massive database in the future.