Decreasing of Oxidative Stress of Red Tamarillo (Solanum Betaceum Cav.) Extract in STZ-NA-Induced Diabetic Rats

Abstract

: The objectivity of the research investigated tamarillo extract to decreasing of oxidative stress in STZ-NA induced diabetic Sprague Dawley rats including its mechanism. The method used complete random designs with six groups of male Sprague Dawley rats, every 5 rats. The groups were three groups control such as one healthy rat as healthy control (COS); two diabetes groups: not treated as a negative control (CON) and given metformin drug as a positive control (COP); three diabetes groups another with tamarillo extract treatments such as: given ethanol extract (more anthocyanin) as a DEE; given acetone extract (more carotenoid) as DEE and given both mixtures as DMEEA. The result showed MDA increased and SOD decreased in diabetes control rats compared to healthy control rats. Intervention with ethanol extract, acetone extract and its mixture for 28 days significantly decreased oxidative stress by decreasing of MDA and increasing of SOD. The mechanism of its pathway was by decreasing of malondialdehyde, increasing of superoxide dismutase so could be repairing of pancreas Langerhans islet following improving β -cells function, then increasing of insulin, moreover could decreasing of blood sugar.