Prognostic value of morphometry in papillary thyroid carcinoma

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Pub Date : 1989-03-01 DOI:10.1109/IEMBS.1988.94527

R. Ambros, R. Trost, A. Campbell, W. Lambert

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引用次数: 27

Abstract

The value of morphometric analysis in addition to standard prognostic indicators was studied in 28 cases of papillary thyroid carcinoma. The mean follow up was 47 months. Recurrences occurred in six patients at a mean time of 34 months, five with distal metastases and one with local disease. Univariate analysis most closely associated recurrence with nuclear anisotropism (the standard deviation of the estimated nuclear area (NASD)) and tumor size. With forward stepwise incremental analysis, the value of tumor size was lost and only the ENASD and the cellularity mean index (CMI), defined as the percentage of tumor volume composed of tumor cells significantly correlated with recurrence. 55% of patients with a ENASD>17 mu m/sup 2/ and a CMI>40% developed recurrence as compared to 5% of patients with lesser values (p=0.0001). Morphometric analysis may significantly contribute to the role of histopathology in the evaluation of papillary thyroid carcinoma and provide information regarding prognosis not obtained by standard methods.<>

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形态测量在甲状腺乳头状癌中的预后价值

本文对28例甲状腺乳头状癌的形态学分析和标准预后指标进行了探讨。平均随访时间为47个月。6例患者复发，平均时间34个月，5例远端转移，1例局部病变。单因素分析与核各向异性(估计核面积的标准偏差(NASD))和肿瘤大小密切相关。在逐步分析中，肿瘤大小的值丢失，只有ENASD和细胞平均指数(cellarity mean index, CMI)与复发显著相关，CMI定义为肿瘤细胞占肿瘤体积的百分比。ENASD>17 μ m/sup 2/和CMI>40%的患者中有55%的患者复发，而较小值的患者中有5%复发(p=0.0001)。形态计量学分析可以显著促进组织病理学在甲状腺乳头状癌评估中的作用，并提供标准方法无法获得的预后信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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