Eulerian path methods for multiple sequence alignment

M. Waterman, Yu Zhang
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引用次数: 2

Abstract

With the rapid increase in the size of genome sequence databases, the multiple sequence alignment problem is increasingly important and often requires the alignment of a large number of sequences. Beginning in 1975, many heuristic algorithms have been created to improve the speed of computation and the quality of alignment. We introduce a novel approach that is fundamentally distinct from all currently available methods. Our motivation comes from the Eulerian method for fragment assembly in DNA sequence determination, that transforms all the DNA sequencing fragments into a de Bruijn graph and then reduces sequence assembly to a Eulerian path problem.
多序列比对的欧拉路径方法
随着基因组序列数据库规模的迅速增加,多序列比对问题日益重要,往往需要对大量序列进行比对。从1975年开始,人们创建了许多启发式算法来提高计算速度和对齐质量。我们介绍了一种新颖的方法,从根本上不同于所有现有的方法。我们的动机来自于DNA序列确定中片段组装的欧拉方法,该方法将所有DNA测序片段转换成de Bruijn图,然后将序列组装简化为欧拉路径问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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