Nonlinear analysis of cardiac optical mapping data reveals ordered period in defibrillation failure

Abstract

A high-speed video camera and voltage-sensitive dyes were used to acquire high resolution (80times80 pixels) and high-speed (500mus/frame) optical signals of ventricular fibrillation in a Langendorff-perfused porcine heart. The resulting spatiotemporal dynamics were recorded before and after the application of a defibrillation shock in order to study the mechanism of defibrillation failure. We used recurrence plots as a tool to qualify the evolution of ordered behavior on the heart surface before fibrillation was reestablished in defibrillation failure. Such ordered periods may point to robust periods in which the defibrillation attempt has had the most effect and may provide a window in which a smaller, corrective shock may be applied to achieve defibrillation