{"title":"Photonic crystal nanoslot nanolaser for super-sensitivity bio-sensing","authors":"T. Baba, S. Kita, S. Hachuda, S. Otsuka","doi":"10.1109/ICTON.2012.6253863","DOIUrl":null,"url":null,"abstract":"High-performance and low-cost sensors are critical devices for high-throughput analyses of bio-samples in medical diagnoses and life sciences. This report demonstrates GaInAsP photonic crystal nanolaser sensor, which detects the adsorption of bio-molecules from the lasing wavelength shift. It is a promising device, which balances a high sensitivity, high resolution, small size, easy integration, simple setup and low cost. In particular with a nanoslot structure, it achieves a super-sensitivity in protein sensing whose detection limit is 3-5 orders of magnitude lower than that of standard surface-plasmon-resonance sensors, e.g. ~ 100 fM order for BSA and <; 1 aM for streptavidin. Our investigations suggest a candidate mechanism that the nanoslot acts as a protein condenser powered by the optical gradient force, which arises from the strong localization of laser mode in the nanoslot.","PeriodicalId":217442,"journal":{"name":"2012 14th International Conference on Transparent Optical Networks (ICTON)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2012-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2012 14th International Conference on Transparent Optical Networks (ICTON)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICTON.2012.6253863","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
High-performance and low-cost sensors are critical devices for high-throughput analyses of bio-samples in medical diagnoses and life sciences. This report demonstrates GaInAsP photonic crystal nanolaser sensor, which detects the adsorption of bio-molecules from the lasing wavelength shift. It is a promising device, which balances a high sensitivity, high resolution, small size, easy integration, simple setup and low cost. In particular with a nanoslot structure, it achieves a super-sensitivity in protein sensing whose detection limit is 3-5 orders of magnitude lower than that of standard surface-plasmon-resonance sensors, e.g. ~ 100 fM order for BSA and <; 1 aM for streptavidin. Our investigations suggest a candidate mechanism that the nanoslot acts as a protein condenser powered by the optical gradient force, which arises from the strong localization of laser mode in the nanoslot.