Differences of Relationships between Iodine and Some Chemical Elements in Normal Thyroid and Thyroid Benign Nodules Revealed by Neutron Activation and Inductively Coupled Plasma Atomic Emission Spectrometry

Women's Health Science Journal Pub Date : 1900-01-01 DOI:10.23880/whsj-16000173

V. Zaichick

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Abstract

Thyroid benign nodules (TBN) are the most common lesions of this endocrine gland. The etiology of TBN is not clear. The aim of this exploratory study was to examine differences in the content of such chemical elements (ChEs) as Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V and Zn, as well as differences in I/ChEs content ratios in tissues of normal thyroid and TBN. Thyroid tissue levels of ChEs were prospectively evaluated in 105 apparently healthy persons and in 79 patients with TBN. Measurements were performed using neutron activation analysis combined with inductively coupled plasma atomic emission spectrometry. It was observed that in TBN the mass fraction of Al, B, Br, Cl, Cu, Fe, Li, Mn, Na, P, S, Si, V, and Zn were higher whereas mass fractions of Ca and I were lower than in normal tissues of the thyroid. It was found also that the I/Al, I/B, I/Br, I/Cl, I/Cu, I/K, I/Mg, I/Mn, I/Na, I/P, I/S, and I/Zn mass fraction ratios in TBN were significantly lower the normal levels. Furthermore, it was shown that the levels of Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V and Zn contents in the normal and affected thyroid gland were interconnected and depend on the content of I in thyroid tissue. Because I plays a decisive role in the function of the thyroid gland, the data obtained allow us to conclude that, along with I, such ChEs as Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V and Zn, if not directly, then indirectly, are involved in the process of thyroid hormone synthesis. It follows that for the normal functioning of the thyroid gland, it is necessary to maintain an adequate concentration of I in its tissue, balanced with the levels of other ChE. An imbalance between I content and levels of other ChEs in the thyroid gland may be one of the causes of nodular neoplasms

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中子活化与电感耦合等离子体原子发射光谱分析正常甲状腺与良性甲状腺结节中碘与某些化学元素的关系差异

甲状腺良性结节(TBN)是这种内分泌腺最常见的病变。TBN的病因尚不清楚。本探索性研究的目的是检测正常甲状腺和TBN组织中Al、B、Ba、Br、Ca、Cl、Cu、Fe、I、K、Li、Mg、Mn、Na、P、S、Si、Sr、V、Zn等化学元素(ChEs)含量的差异，以及I/ChEs含量比的差异。在105名表面健康的人和79名TBN患者中，前瞻性地评估了甲状腺组织中的ChEs水平。测量采用中子活化分析结合电感耦合等离子体原子发射光谱法。观察到，在TBN中，Al、B、Br、Cl、Cu、Fe、Li、Mn、Na、P、S、Si、V和Zn的质量分数高于正常甲状腺组织，而Ca和I的质量分数低于正常甲状腺组织。TBN中I/Al、I/B、I/Br、I/Cl、I/Cu、I/K、I/Mg、I/Mn、I/Na、I/P、I/S和I/Zn的质量分数比显著低于正常水平。此外，正常甲状腺和病变甲状腺中Al、B、Ba、Br、Ca、Cl、Cu、Fe、I、K、Li、Mg、Mn、Na、P、S、Si、Sr、V和Zn的含量相互关联，并依赖于甲状腺组织中I的含量。由于I在甲状腺的功能中起着决定性的作用，所获得的数据使我们能够得出这样的结论:与I一起，Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V和Zn等ch即使不是直接参与，也会间接参与甲状腺激素的合成过程。因此，为了甲状腺的正常功能，有必要在其组织中保持足够的I浓度，与其他ChE水平保持平衡。甲状腺中I含量与其他che水平的不平衡可能是结节性肿瘤的原因之一

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Women's Health Science Journal

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