Clinical characteristics of anti-Jo-1-positive interstitial lung disease

Abstract

Anti-Jo-1-syndrome is the most common form of antisynthetase syndrome, which often presents with interstitial lung disease (ILD) and polymyositis/dermatomyositis(PM/DM). Little is understood how the presence of PM/DM affects the clinical presentation of ILD patients with anti-Jo-1-antibody (Jo-1-ILD). We aim to characterize Jo-1-ILD by comparing patients with PM/DM (PM/DM-ILD) and without PM/DM (non-PM/DM-ILD). In this retrospective review, 49 Jo-1-ILD patients diagnosed at our institution from January 2005 to June 2018 were included. Clinical, radiologic, and histologic features of 20 PM/DM-ILD and 29 non-PM/DM-ILD patients were compared. PM/DM-ILD patients were younger at ILD diagnosis than non-PM/DM-ILD (51.0 years vs. 64.5 years, p PM/DM-ILD and non-PM/DM-ILD show similar clinical characteristics, except for age at diagnosis, anti-Ro status and medical treatment. The presence of PM/DM does not significantly affect the clinical course of Jo-1-ILD.