From 2D To 3D, Advances of Technology and Instrumentation for Stem Cell Culture in Vitro

2021 IEEE 15th International Conference on Electronic Measurement & Instruments (ICEMI) Pub Date : 2021-10-29 DOI:10.1109/ICEMI52946.2021.9679615

Muhang Li, Junning Cui, Ran Tang

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Abstract

Stem cell therapy is a strategic and prospective scientific issue in the international arena. It is of great significance for heart failure, neurodegenerative diseases and many other serious diseases that lack of effective treatments. Large-scale, high-quality, safe and stable stem cell culture technology is a technical bottleneck that restricts the promotion of stem cell therapy. Three-dimensional (3D) culture technology and instruments can significantly improve the production efficiency of stem cells culturing, ensure the production quality, and enhance the therapeutic effects, therefore serves as a foundation for the development of cell therapy filed. In this review, we summarized the working principle of contemporary mainstream 3D stem cell culture instruments as well as their advantages and disadvantages. The future development trend of stem cell culture instrumentation is predicted. Recommendations are proposed for the selection of culturing instruments in stem cell clinical application, and research and development of new technology and instruments in the future.

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从2D到3D，干细胞体外培养技术和仪器的进展

干细胞治疗在国际上是一个具有战略性和前瞻性的科学问题。对于心衰、神经退行性疾病等许多缺乏有效治疗的严重疾病具有重要意义。大规模、高质量、安全稳定的干细胞培养技术是制约干细胞治疗推广的技术瓶颈。三维(3D)培养技术和仪器可以显著提高干细胞培养的生产效率，保证生产质量，增强治疗效果，为细胞治疗领域的发展奠定了基础。本文综述了当前主流3D干细胞培养仪器的工作原理及其优缺点。展望了干细胞培养仪器的未来发展趋势。对今后干细胞临床应用中培养仪器的选择和新技术、新仪器的研发提出了建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2021 IEEE 15th International Conference on Electronic Measurement & Instruments (ICEMI)

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