The Protective Effect of Blue Light Cutting Particles Mixed Optical Material against Blue LED Light-Induced Photoreceptor and Cornea Cell Death

Tomohiro Yako, Yoshiki Kuse, Shinsuke Nakamura, M. Shimazawa, T. Motomura, H. Hara
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Abstract

Blue light emitting diode (LED) light is being used various devices for recent decades. Blue LED light has the 450–500 nm wavelengths, and high photon energy compared with green or red LED light. It is known that the exposure to blue LED light causes retinal photoreceptor cells damage. It is unknown whether the blue LED light cut particle containing lens has a protective effect against blue LED light-induced cell damage although the absorbance by colored lens shows a protective effect. Thus, the purpose of this study was to reveal that the protective effect of blue LED light cutting particle containing lens against photoreceptor and corneal epithelial cell damage induced by blue LED light exposure. We irradiated blue LED light to the mouse photoreceptor cells and human cornea epithelial cells with or without lens. The lens containing about one third blue LED light cutting particle (TECHPOLYMER) decreased production of reactive oxygen species and improved cell death rate and cell viability rate. These findings show that TECHPOLYMER containing lens may protect photoreceptor and cornea cells by reducing of reactive
蓝光切割颗粒混合光学材料对蓝光LED光致感光细胞和角膜细胞死亡的保护作用
近几十年来,蓝色发光二极管(LED)被用于各种设备。蓝色LED光的波长为450 - 500nm,与绿色或红色LED光相比,其光子能量更高。众所周知,暴露在蓝色LED光下会导致视网膜感光细胞受损。含蓝光LED光切割颗粒的晶状体对蓝光LED光致细胞损伤是否具有保护作用尚不清楚,但有色晶状体的吸光度显示出保护作用。因此,本研究的目的是揭示含晶状体蓝光LED切割颗粒对蓝光LED光照射引起的角膜感光细胞和角膜上皮细胞损伤的保护作用。我们将蓝光LED照射到有晶状体或不带晶状体的小鼠光感受器细胞和人角膜上皮细胞。含有约三分之一蓝色LED光切割颗粒(TECHPOLYMER)的透镜减少了活性氧的产生,提高了细胞死亡率和细胞存活率。这些结果表明含TECHPOLYMER的晶状体可能通过降低反应性来保护感光细胞和角膜细胞
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