The Biochemical and Histological Effects of Tramadol on Liver and Kidney of Albino Mice

Abstract

The aim of this study is to assess the effect of usage of tramadol in liver and kidney in albino mice. Twenty albino mice were taken (25-30) gm and divided in to two groups, group I (10 mice) which received normal saline intramuscularly and group II (10 mice) which received ) 25 mg /kg body weight ( daily of tramadol intramuscularly for 40 days, the biochemical assay showed significant increase (p value < 0.05) in the Aspartate aminotransferase (AST), alanine aminotransferase (ALT), Urea and Creatinine in experimental group compared to the control group. The histological examination regarded for liver tissues degenerative changes in the hepatocytes, dilated central vein, focal necrotic area, congested vessel, congested hepatic vein and cytolysis while kidney tissues show widening bowman capsule, interstitial nephritis, necrosis, degenerative change, lymphocyte infiltration in renal interstitial nephritis and degenerative changes in renal proximal tubules. Table (1) show effect of tramadol on Serum Alanine Aminotransferase (ALT) and Serum Aspartate Aminotransferase (AST) * refer to significant differences between compared mean, ** refer to highly significant increase between compared mean. Table (2) show the effect of tramadol on blood urea and serum creatinine, * refer to significant differences between compared mean.