System calibration and statistical image reconstruction for sub-mm stationary pinhole SPECT

IEEE Nuclear Science Symposium Conference Record, 2005 Pub Date : 1900-01-01 DOI:10.1109/NSSMIC.2005.1596883

F. van der Have, B. Vastenhouw, M. Rentmeester, F. Beekman

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引用次数: 14

Abstract

Iterative SPECT reconstruction requires position-dependent point spread functions (PSFs) specifying the response of the detectors to a point source at every position in the instrument. To obtain accurately reconstructed images, the PSFs should incorporate all important effects of photon transport and imaging geometry. The PSFs can be measured directly, but measuring in each voxel of the object space can be impractical for sub-mm-resolution instruments. This study describes a method for generating complete PSF lookup tables from a limited number of point source measurements for a stationary small-animal SPECT system with 75 pinholes (U-SPECT-I, J. Nucl. Med., 2005, pp. 1194-1200). The method is based on modeling the shape of the PSFs, measured at a limited number of positions. Subsequently the model parameters are generalized to estimate and shape PSFs at missing positions. The method enables us to obtain 0.45 mm reconstructed resolution with 0.6 mm pinholes and 0.35 mm resolution with 0.3 mm pinholes with a SPECT system which has 3.2 mm intrinsic detector resolution

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亚毫米固定针孔SPECT系统标定与统计图像重建

迭代SPECT重建需要位置相关的点扩展函数(psf)来指定探测器对仪器中每个位置的点源的响应。为了获得精确的重建图像，psf应该结合光子传输和成像几何的所有重要影响。psf可以直接测量，但是对于亚毫米分辨率的仪器来说，测量物体空间的每个体素是不切实际的。本研究描述了一种从固定的75个针孔的小动物SPECT系统的有限数量的点源测量中生成完整PSF查找表的方法(U-SPECT-I, J. Nucl)。医学，2005年，第1194-1200页)。该方法基于对psf的形状进行建模，在有限的位置进行测量。然后将模型参数推广到缺失位置的psf估计和形状。该方法使我们能够用0.6 mm针孔获得0.45 mm的重建分辨率，用3.2 mm的内禀探测器分辨率的SPECT系统获得0.3 mm针孔的0.35 mm分辨率

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IEEE Nuclear Science Symposium Conference Record, 2005

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