In vivo study of percutaneous absorption of lidocaine using electret in the rat

Abstract

The present work was undertaken to study the effect of electret on transdermal drug delivery in vivo. The experiment was carried out in depilated abdominal rat skin using lidocaine hydrochloride as a model compound. Rats were divided into control and electret group. The electrets were applied on the drug in a vial and the blood samples were taken from jugular vein at predetermined time intervals. The concentration of lidocaine in plasma was measured by high proficiency liquid chromatograph (HPLC) after extraction. The plasma lidocaine concentration was significantly increased in electret group. The results suggested that electret could promote the permeability of drug by its effect on the structure of epidermis and blood flow change.