S72 Lung function outcomes in children with paediatric inflammatory multisystem syndrome – temporally associated with SARS-CoV-2 (PIMS-TS)

Abstract

S72 Table 1Table of lung function results expressed as mean and 95% CI = Confidence IntervalDemographic N= Mean (95% CI) Age (years) N= 30 11.73 (10.70, 12.77) Sex, Female% N=14 (48%) Height (cm) N=30 152.24 (145.62, 158.86) FeNO (ppb) N=26 16.28 (9.01, 23.55) FEV1%pred (%) N=29 103.85 (98.04, 109.66) FEV1 z-score N= 29 0.32 (0.00, 1.00) FVC%pred (%) N= 29 103.3 (98.25, 108.35) FVC z-score N= 29 0.25 (-0.15, 0.66) FEV1:FVC Ratio%pred (%) N= 29 98.84 (96.69, 100.99) FEV1:FVC Ratio z-score N=29 -0.09 (-0.41, 0.23) TLCO%pred N=23 86.69 (80.00, 93.39) TLCO z-score N=23 -1.04 (-1.70, -0.37) KCO%pred N=23 97.22 (91.34, 103.01) KCO z-score N=23 -0.22 (-0.65, 0.21) VA%pred N=23 88.87 (84.09, 93.65) VA z-score N=23 -1.01 (-1.44, -0.58) FRCpleth%pred (%) N=15 88.00 (80.99, 95.01) FRCpleth z-score N=15 -0.77 (-1.26, -0.28) TLC%pred (%) N=15 98.2 (92.17, 104.23) TLC z-score N=15 -0.15 (-0.66, 0.36) RV%pred (%) N=15 83.47 (71.34, 95.60) RV z-score N=15 -0.43 (-0.88, 0.02) ConclusionSimilar to other systemic inflammatory syndromes (Staphylococcal toxic shock, Kawasaki disease), and unlike Covid-19 in adults, it appears that children’s lungs are at low risk of long term damage by PIMS-TS. This data is preliminary and we have not assessed exercise tolerance, or outcomes in those with presentations that did not require initial respiratory support. Assessments are ongoing in this cohort and in children presenting following infection with new variants of concern.ReferencePenner, et al. 6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a retrospective cohort study. Lancet Child Adolesc Health 2021;5(7):473–482.