Synthesis, Characterization and Electrospinning of Novel Chitosan Derivative for Tissue Engineering Applications

Abstract

Synthesis of quaternized tetramethyl urea thiosemicarbazone O-carboxymethyl chitosan (CMC) as a new quaternized chitosan derivation and electrospinning of quaternized tetramethyl urea thiosemicarbazone CMC/poly (vinyl alcohol) blend solution was investigated. The chemical structure and morphology of the nanofibers were observed by Fourier transform infrared spectra analysis and scanning electron microscopy (SEM). The results indicate that prepared nanofiber may be a new candidate for tissue engineering purposes.