[Hypotrypsinemia in diabetes mellitus].

Acta medica Austriaca. Supplement Pub Date : 1979-01-01
G Schernthaner, I Mühlhauser, R Willvonseder
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Abstract

Plasma concentrations of immune-reactive trypsin (IRT) were determined in 212 patients with juvenile-onset, insulin-dependent diabetes (Type I) and in 158 patients with maturity onset diabetes (Type II) in comparison to 121 healthy individuals. Significantly increased IRT levels were obtained in the type I diabetics, whereas IRT concentrations were normal or increased in the type II diabetic patients. Hypotrypsinemia occurred predominantly in type I diabetics with high IgG-insulin antibodies or islet-cell antibodies. No correlation was noted between the IRT-levels and the beta-cell residual capacity in the type-I diabetics.

[糖尿病患者的低胰蛋白酶血症]。
测定了212例青少年发病胰岛素依赖型糖尿病(I型)患者和158例成年发病糖尿病(II型)患者的血浆免疫反应性胰蛋白酶(IRT)浓度,并与121名健康个体进行了比较。I型糖尿病患者的IRT水平显著升高,而II型糖尿病患者的IRT浓度正常或升高。低胰蛋白酶血症主要发生在具有高igg -胰岛素抗体或胰岛细胞抗体的I型糖尿病患者。在i型糖尿病患者中,irt水平与β细胞剩余容量之间没有相关性。
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