Molecularly imprinted microspheres prepared by precipitation polymerization at high monomer concentrations

Tibor Renkecz, K. László, V. Horváth
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引用次数: 26

Abstract

Abstract Highly crosslinked polymer microparticles have been prepared by precipitation polymerization using high monomer loadings (≥25 v/v %) which generally would lead to bulk monoliths. The microparticle format was achieved by the use of non-solvating diluents either alone or in combination with co-solvents. Two distinct morphologies were observed. Monodisperse smooth microspheres were obtained using a thermodynamically good co-solvent whereas segmented irregular particles were formed with poorer co-solvents. It has been found that during polymerization the forming polymer particles were enriched in the co-solvent and this effect was more pronounced when good co-solvents were used. The type of functional monomer, crosslinker and co-solvent, and the non-solvent/co-solvent ratio were identified as influential parameters on the microparticle morphology. With the proposed methodology molecularly imprinted microparticles have been prepared successfully for three different templates, naproxen, diclofenac and toltrazuril using various functional monomers, crosslinkers and polymerization solvent mixtures.
高单体浓度沉淀聚合制备分子印迹微球
采用高单体负载(≥25 v/v %)的沉淀聚合法制备了高交联聚合物微粒,而高单体负载通常会导致大块的单体。通过单独使用非溶剂化稀释剂或与助溶剂结合使用,实现了微粒格式。观察到两种不同的形态。使用热力学良好的助溶剂可得到单分散的光滑微球,而使用热力学较差的助溶剂则可形成分段的不规则颗粒。研究发现,在聚合过程中,形成的聚合物颗粒在助溶剂中富集,当使用好的助溶剂时,这种效果更为明显。确定了功能单体类型、交联剂和共溶剂、非溶剂/共溶剂比是影响微球形貌的主要因素。利用所提出的方法,利用不同的功能单体、交联剂和聚合溶剂混合物,成功地制备了萘普生、双氯芬酸和托曲祖利三种不同模板的分子印迹微粒。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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