Correlation of induced sputum eosinophil, absolute eosinophil count and serum IgE with clinical severity of bronchial asthma

G. Purohit, V. Sharma, C. R. Choudhary, Hemant Borana, B. Choudhary
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Abstract

Background: Asthma is a chronic inflammatory disorder of the airway. Eosinophil and Serum IgE being a marker of airway inflammation, can serve as a tool for assessing severity and response to treatment in asthma patients. The correlation of clinical assessment with various markers of airway inflammation in asthma is not well established in the Indian population. Present study correlates induced sputum eosinophil, blood eosinophil and Serum IgE count in assessing the clinical severity in bronchial asthma. Aims: To study the correlation of sputum eosinophil, absolute eosinophil count and Serum IgE in assessing the clinical severity of asthma. Methods: It was a cross sectional quantitative study, which was carried out between Feb 2020 to feb 2021. Total 70 asthmatics was selected which underwent history, examinations and spirometry, after written consent. Severity of asthma was assessed by clinical features and by FEV1 in spirometry. (as per GINA guidelines). After assessing the severity of Bronchial asthma all patient underwent Sputum examination for sputum eosinophil counts, blood sampling for Absolue eosinophil counts and Serum IgE levels. After that sputum eosinophil counts, absolute eosinophil counts and serum IgE levels were correlated with severity of Bronchial Asthma. Conclusion: Assessment of eosinophil count in sputum and blood, and serum IgE in blood are simple and inexpensive method that can show a direct measurement of airway inflammation. Thus it can help to identify specific phenotypes in asthmatic patients who are more responsive to steroids, which needs to be demonstrated in future studies. It could be the preferred method in routine practice in monitoring airway inflammation and guiding management.
诱导痰嗜酸性粒细胞、绝对嗜酸性粒细胞计数及血清IgE与支气管哮喘临床严重程度的相关性
背景:哮喘是一种慢性气道炎症性疾病。嗜酸性粒细胞和血清IgE是气道炎症的标志物,可以作为评估哮喘患者严重程度和治疗反应的工具。临床评估与哮喘气道炎症的各种标志物的相关性在印度人群中尚未很好地建立。本研究将诱导的痰嗜酸性粒细胞、血嗜酸性粒细胞和血清IgE计数与支气管哮喘临床严重程度的评价联系起来。目的:探讨痰嗜酸性粒细胞、绝对嗜酸性粒细胞计数与血清IgE在哮喘临床严重程度评价中的相关性。方法:采用横断面定量研究,于2020年2月~ 2021年2月进行。选择70例哮喘患者,经书面同意后进行病史、检查和肺活量测定。通过临床特征和肺活量测定FEV1来评估哮喘的严重程度。(根据GINA指南)。在评估支气管哮喘的严重程度后,所有患者都进行了痰嗜酸性粒细胞计数、绝对嗜酸性粒细胞计数和血清IgE水平的抽血检查。痰嗜酸性粒细胞计数、绝对嗜酸性粒细胞计数和血清IgE水平与支气管哮喘的严重程度相关。结论:痰、血中嗜酸性粒细胞计数及血中血清IgE的测定是一种简便、廉价的方法,可直接测量气道炎症。因此,它可以帮助识别对类固醇反应更敏感的哮喘患者的特定表型,这需要在未来的研究中得到证实。它可作为常规临床监测气道炎症和指导治疗的首选方法。
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