The Effect Of Insulin Induced Acute Hypoglycemia on Brain Neurotransmitters and Oxidative Stress , Possible Protection by Gabapentin And Olanzapine

Abstract

is can cause Aim , The study designed to test the effect of acute insulin induced hypoglycemia on: 1)the brain oxidative status as measured by Malondialdehyde (MDA). 2)brain neurotransmitters; dopamine, ɣ-Amino butyric acid (GABA)and noradrenaline. And Possible protective effect of gabapentin and olanzapine against hypoglycemia. Method and Materials, 32 male rabbits, randomly divided into four groups, group A (control group) treated with (2.5ml/kg) distilled water orally and (0.1 ml/kg) distilled water subcutaneously. Group B (Hypoglycemic group) treated with (2.5ml/kg) distilled water orally and (1 IU/kg) insulin subcutaneously. decreased of noradrenaline in comparison to use insulin only. Conclusion, Insulin hypoglycemia lead to oxidative stress and brain neurotransmitters disturbance which are partly reversed by gabapentin and olanzapine, on the other hand both drugs tend to exacerbate insulin induced hypoglycemia. Caution should be excreted when giving any of the two drugs in such situation.