The upregulation of Myb and Peg3 may mediate EGCG inhibition effect on mouse lung adenocarcinoma

Hong Zhou, Joseph Manthey, E. Lioutikova, Mary Yang, William Yang, K. Yoshigoe, Hong Wang
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Abstract

The antioxidant activity of green tea polyphenol epigallocatechin-3-gallate (EGCG) has been found to be critical in inhibiting carcinogenesis. In our previous study, we identified a set of protein coding genes and microRNAs whose expressions were significantly modulated in response to the EGCG treatment in tobacco carcinogen-induced lung adenocarcinoma in A/J mice. In this study, we further conducted some statistical analysis on our microarray data and employed The Cancer Genome Atlas (TCGA) lung adenocarcinoma datasets as additional control. We postulated that if a gene mediates EGCG's cancer inhibition, its expression level change caused by EGCG should be opposite to what occurred in the carcinogenesis. With this assumption, we identified Myb and Peg3 as the primary genes involved in the cancer inhibitory activities of EGCG.
上调Myb和Peg3可能介导EGCG对小鼠肺腺癌的抑制作用
绿茶多酚表没食子儿茶素-3-没食子酸酯(EGCG)的抗氧化活性已被发现对抑制癌变至关重要。在我们之前的研究中,我们发现了一组蛋白编码基因和microrna,它们的表达在EGCG治疗烟草致癌物质诱导的a /J小鼠肺腺癌中被显著调节。在本研究中,我们进一步对我们的微阵列数据进行了一些统计分析,并使用The Cancer Genome Atlas (TCGA)肺腺癌数据集作为额外的对照。我们推测,如果一个基因介导了EGCG的抑癌作用,那么EGCG引起的基因表达水平变化应该与癌变过程相反。基于这一假设,我们确定了Myb和Peg3是参与EGCG抑癌活性的主要基因。
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