CONCEPTS AND METHODS

Abstract

The mucolipin subgroup of the transient receptor potential superfamily of cation channels (TRPMLs) are evolutionarily conserved non-selective cation channels that function in endolysosomal membranes, and play key roles in the regulation of endocytosis, autophagy, and intracellular trafficking. Mammalian genomes encode three TRPML paralogs – TRPML1, TRPML2, and TRPML3 – that differ in tissue Ion and Molecule Transport in Lysosomes TRPML Subfamily