Continuous active probing and modulation of neural networks with a wireless implantable system

Abstract

The optimal epilepsy management device requires: 1) automated seizure detection 2) accurate automated electronic seizure diaries 3) seizure forecasting 4) active brain probing to track brain state and 5) automated brain stimulation therapy adjustment that can respond to changes in seizure probability to prevent seizures. In this paper, we describe an epilepsy management and therapy platform using Medtronic's investigational Activa RC+S Research System. The investigational Activa RC+S provides chronic nervous system stimulation, sensing, and embedded analytics. Continuous iEEG telemetry from the RC+S device can be received by a handheld or tablet computer providing more advanced analytical capability. The combined platform provides a unique opportunity for exploring and managing epileptic neurophysiology.