Organ-preserving surgery of localized kidney cancer with preliminary superselective embolization of the tumor-feeding branch of renal artery.

Сергій Віталійович Попов, Р. Г. Гусейнов, И. Н. Орлов, С.Г. Винцковский, Е. В. Помешкин, О.Н. Скрябин, Б. А. Неймарк, В. В. Перепелица, А.Н. Архипов, М. М. Мирзабеков, А.С. Катунин, К. В. Сивак, Н. С. Буненков, А. С. Улитина, S. Popov, R. Guseynov, I. Orlov, S. G. Vintskovsky, E. Pomeshkin, O. Skryabin, B. Neymark, V. V. Perepelitsa, A. Arkhipov, M. M. Mirzabekov, A. Katunin, K. V. Sivak, N. S. Bunenkov, A. S. Ulitina, Клиническое Исследование
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Abstract

Introduction. Warm renal ischemia (WRI) is used during the organ-preserving surgery of localized renal cell carcinoma to reduce blood loss, improve the imaging quality, facilitate both accessing the cavitary system and suturing the parenchyma. However, WRI can lead to the ischemic reperfusion injury of the preserved nephrons. Superselective embolization (SSE) of the tumor-feeding branch of renal artery is currently being considered as the alternative method of intraoperative hemostasis. Aim. To evaluate the results of organ-preserving surgery of localized kidney cancer in the conditions of SSE. Materials and methods. Three patients who had undergone laparoscopic kidney resection (LKR) with SSE were included in the study. Parameters for assessment were as follows: surgery duration, surgery workflow, intraoperative blood loss volume, the degree of radical surgery according to the histological data, the presence of postoperative complications, and the duration of hospitalization. Results. Compared with the LKR with WRI (n=78, data from a previous own study), the features of the LRK with SSE (n=3) were as follows: 1) the same surgery duration; 2) three times less intraoperative blood loss; 3) the absence of infectious and inflammatory complications; 4) comparable duration of hospitalization. Also, additional advantages of the LKR with SSE were described: 1) the radicality of surgery; 2) the absence of the risk of renal pedicle injury; 3) the absence of the risk of ischemic reperfusion alteration of the preserved renal tissue. Conclusion. Preliminary SSE of the tumor-feeding branch of renal artery may improve functional results of the organ-preserving surgery of localized kidney cancer via reducing the intraoperative blood loss, exclusion the possibility of renal pedicle injury, and provision of the functional activity of the preserved nephrons.
局部肾癌的器官保留手术与肾动脉肿瘤供血分支的初步超选择性栓塞。
介绍。温肾缺血(Warm renal ischemia, WRI)是局部肾细胞癌保脏器手术中使用的一种方法,可以减少出血量,提高成像质量,方便进入腔室系统和缝合实质。然而,WRI可导致保存的肾单位缺血再灌注损伤。肾动脉肿瘤供血分支的超选择性栓塞(SSE)目前被认为是术中止血的替代方法。的目标。目的评价SSE条件下局部肾癌保脏器手术的效果。材料和方法。本研究纳入了3例经腹腔镜肾切除术(LKR)合并SSE的患者。评估参数为:手术时间、手术流程、术中出血量、根据组织学资料进行根治性手术的程度、术后并发症的存在情况、住院时间。结果。与合并WRI的LKR (n=78,数据来自以往自身研究)相比,合并SSE的LRK (n=3)具有以下特点:1)手术时间相同;2)术中出血量减少3倍;3)无感染和炎症并发症;4)住院时间可比。此外,本文还描述了LKR与SSE的其他优点:1)手术的根治性;2)无肾蒂损伤风险;3)保存的肾组织不存在缺血再灌注改变的风险。结论。肾动脉供瘤分支的初步SSE可通过减少术中出血量、排除肾蒂损伤的可能性、提供保留肾单位的功能活性,改善局部肾癌器官保留手术的功能效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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