Navigating the Changing Multiple Myeloma Treatment Landscape

Abstract

The treatment landscape for patients with multiple myeloma (MM) is constantly evolving. Over the past decade, the introduction of novel agents including proteasome inhibitors (PI) and immunomodulatory agents has led to notable changes in therapeutic strategy and significant improvements in survival. Understanding this landscape and what this means in terms of translating clinical trials to everyday practice is essential. Prof Paul Richardson opened the symposia with an introduction to currently available agents and recent developments in MM, and highlighted the importance of how we think about current studies. Prof Roman Hájek explored clonal evolution, how it can be prevented in the context of relapsed disease, and the evidence from clinical trials supporting the use of combination therapy. Dr Antonio Palumbo addressed the concept of continuous therapy in MM and where the field is at present. Prof Shaji Kumar described the early phase development of ixazomib. Prof Paul Richardson presented the results from the TOURMALINE-MM1 trial.