Safety and Efficacy of Prgabalin as a Part of Multimodal Analgesia in Patients with Lumbar Spine Disk Surgery

Abstract

Pregabalin was synthesized in 1991 and approved for the treatment of neuropathic pain and refractory epilepsy in 2004 and It is one of two available a 2-d ligands, pregabalin and gabapentin, known as the gabapentinoids. Pregabalin and gabapentin share a similar mechanism of action with the difference related to pharmacokinetic and pharmacodynamic characteristics, and pregabalin has a faster onset time and a more predictable absorption profile than gabapentin. [1-2] Surgical and conservative treatments had longterm beneficial effects on sciatica symptoms in patients with lumbar disc herniation. Compared with conservative treatment, surgical treatment relieved back pain faster, but no relevant clinical difference was observed after 3 months. Surgical treatment may thus be attractive to patients with debilitating pain symptoms who seek quick relief, or who did not experience satisfactory improvement with conservative treatment. [3-4] Abstract