High Throughput Screening System for screening of 3D cell cultures

C. Gallert, R. Lehmann, T. Roddelkopf, S. Junginger, K. Thurow
{"title":"High Throughput Screening System for screening of 3D cell cultures","authors":"C. Gallert, R. Lehmann, T. Roddelkopf, S. Junginger, K. Thurow","doi":"10.1109/I2MTC.2015.7151461","DOIUrl":null,"url":null,"abstract":"Cancer is always an intensively studied field due to an increasing number of incidences. Therapeutic strategies are often associated with negative side effects, which should be minimized. Therefore, natural drugs provide an interesting prospect for cancer therapy by less toxic adverse effects. To test a high number of drugs, automation offers a good approach for the realization of a higher sample throughput. This paper presents a High Throughput Screening System to investigate the effect of different drugs on 3D cell cultures (celisca, Rostock, Germany). We used 3D cell cultures because of their higher similarity to physiological conditions due to the structure. Referring to the High Throughput Screening system, the arrangement is equipped with specific devices to perform a high throughput drug screening. Here, the instrumentation and possibilities of data measurement are described. In conclusion, this screening system could be used in industry for a drug screening in a high throughput manner, which is based on 3D cell cultures.","PeriodicalId":424006,"journal":{"name":"2015 IEEE International Instrumentation and Measurement Technology Conference (I2MTC) Proceedings","volume":"7 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2015 IEEE International Instrumentation and Measurement Technology Conference (I2MTC) Proceedings","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/I2MTC.2015.7151461","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

Cancer is always an intensively studied field due to an increasing number of incidences. Therapeutic strategies are often associated with negative side effects, which should be minimized. Therefore, natural drugs provide an interesting prospect for cancer therapy by less toxic adverse effects. To test a high number of drugs, automation offers a good approach for the realization of a higher sample throughput. This paper presents a High Throughput Screening System to investigate the effect of different drugs on 3D cell cultures (celisca, Rostock, Germany). We used 3D cell cultures because of their higher similarity to physiological conditions due to the structure. Referring to the High Throughput Screening system, the arrangement is equipped with specific devices to perform a high throughput drug screening. Here, the instrumentation and possibilities of data measurement are described. In conclusion, this screening system could be used in industry for a drug screening in a high throughput manner, which is based on 3D cell cultures.
高通量筛选系统筛选三维细胞培养
由于发病率不断上升,癌症一直是一个被深入研究的领域。治疗策略往往伴随着负面的副作用,应该尽量减少。因此,天然药物的毒副作用较小,为癌症治疗提供了一个有趣的前景。为了测试大量的药物,自动化为实现更高的样品吞吐量提供了一个很好的方法。本文介绍了一种高通量筛选系统,用于研究不同药物对3D细胞培养的影响(celisca,罗斯托克,德国)。我们使用3D细胞培养,因为它们的结构与生理条件更相似。参照高通量筛选系统,该装置配备特定装置以进行高通量药物筛选。在这里,介绍了仪器和数据测量的可能性。综上所述,该筛选系统可用于基于3D细胞培养的高通量药物筛选。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信