Analysis of Biochemical and Hematological Parameters During the First and Second Wave of SARS-CoV-2 Infection among North-East Indian Cancer Patients

Asian Pacific Journal of Cancer Care Pub Date : 2022-11-10 DOI:10.31557/apjcc.2022.7.4.637-642

Sawmik Das, A. Sarma, B. Das, D. Sarma, R. Barman, M. Bhattacharyya, A. Kataki, A. Rai

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Abstract

Introduction: SARS-CoV-2 (COVID-19) affects respiratory airways as well as the kidneys, hearts etc. This study aims to demonstrate the impact of COVID-19 infection on biochemical and hematological parameters in cancer patients of North-East India. Methods: The study includes biochemical parameters for 907 and hematological parameters for 1103 cancer patients who were tested for COVID-19 between 1st June 2020 and 1st June 2021. All the data were analyzed by the statistical software SPSS (ver20). Results: AST (p = 0.023), GGT (p = 0.026) and Urea (p = 0.004) significantly increased in COVID-19 positive cancer patients compared to negative cancer patients. Eosinophils (p=0.01), eosinophils absolute (p=0.01), monocyte (p=0.04) and MCHC (p=0.01) were significantly decreased in COVID-19 positive cancer patients compared to negative. Various biochemical and haematological parameters analysed in our study were found to be altered between the COVID-19 positive and negative group but their association was not found to be statistically significant. Conclusion: We conclude that in cancer patients of North-East India, significant alterations of biochemical and hematological parameters AST, GGT, Urea, Eosinophils, eosinophils absolute, monocyte and MCHC were found in COVID-19 positive cancer patients compared to negative cancer patients.

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印度东北部癌症患者第一波和第二波SARS-CoV-2感染期间生化和血液学指标分析

简介:SARS-CoV-2 (COVID-19)不仅影响呼吸道，还会影响肾脏、心脏等。本研究旨在研究COVID-19感染对印度东北部癌症患者生化和血液学参数的影响。方法:研究纳入2020年6月1日至2021年6月1日期间接受COVID-19检测的907例癌症患者的生化参数和1103例血液参数。所有数据均采用SPSS (ver20)统计软件进行分析。结果:与阴性肿瘤患者相比，2019冠状病毒病阳性肿瘤患者AST (p = 0.023)、GGT (p = 0.026)、尿素(p = 0.004)明显升高。与阴性患者相比，阳性患者嗜酸性粒细胞(p=0.01)、绝对嗜酸性粒细胞(p=0.01)、单核细胞(p=0.04)和MCHC (p=0.01)均显著降低。在我们的研究中分析的各种生化和血液学参数在COVID-19阳性组和阴性组之间发生了变化，但它们的相关性没有统计学意义。结论:我们认为，在印度东北部的癌症患者中，与阴性癌症患者相比，2019冠状病毒病阳性癌症患者的生化和血液学参数AST、GGT、尿素、嗜酸性粒细胞、绝对嗜酸性粒细胞、单核细胞和MCHC发生了显著变化。

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Asian Pacific Journal of Cancer Care

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