Assessment of the SPF and Anti-Irritating Properties of Sunscreen designed for Retinol users

Pritipadma Panda, Saimanisha Muppidi, Kartheswari Karuturi, Meghana Reddy Moranganti, Sandeep Mukkamala
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Abstract

Vitamin A and its derivatives, also known as retinoids, when applied topically for anti-ageing benefits, typically cause erythema and dryness on the skin, which are considered significant and common side effects. Furthermore, users of topical retinoids, like everyone else, need a sunscreen that protects the skin from harmful sun exposure while simultaneously countering the erythema and dryness of the skin. Retinoids also enhance the rate of skin cell turnover and expose newly produced skin to solar exposure, increasing the risk of sun damage and hyperpigmentation. Since the skin becomes sensitive with topical retinoids, a sunscreen must possess the further benefit of elevated skin resilience, which is much needed with conventional sun protection. ‘‘EI Pro Retinol Sunscreen’’ came up with a new innovative sunscreen with UV protectants and other active ingredients that have calming and soothing properties that minimize erythema and dryness. EI launched the “EI PRO Retinol series,” which includes the “EI PRO Retinol Sunscreen,” to protect the skin from the detrimental effects of ultraviolet rays as well as further irritation and itching caused by retinoid actions on the skin. In this study, researchers attempted to develop and design a sunscreen using a patented sunscreen agent (a combination of water, ethylhexyl methoxy-cinnamate, butyl methoxy-dibenzoyl-methane, benzophenone-3, phospholipids, and 1,3-butylene glycol) and Porphyridium cruentum (marine algae) for skin resilience, antioxidants like ascorbic acid, vitamin E, and soothing agents like carrot seed oil and sodium hyaluronate. Sunscreens are evaluated based on their sun protection factor (SPF), PA rating, and critical wavelength. Usually, sunscreens with an SPF above 50, a PA rating of ++++, and a critical wavelength over 370 nm would offer higher sun protection and block both UVA and UVB rays. The results showed that “EI PRO Retinol Sunscreen” has a critical wavelength of 376.67 and is considered a broad-spectrum SPF 50 PA++++ sunscreen. Thus, ‘‘EI PRO Retinol Sunscreen’’ is also proven to be safe on the skin without irritation, and it is proven to be non-irritant by a single, blinded patch test method.  
为视黄醇使用者设计的防晒霜的SPF和抗刺激性能的评估
维生素A及其衍生物,也被称为类维生素A,当局部用于抗衰老时,通常会导致皮肤红斑和干燥,这被认为是严重和常见的副作用。此外,外用类维生素a的使用者和其他人一样,需要防晒霜来保护皮肤免受有害的阳光照射,同时对抗皮肤的红斑和干燥。类维生素a还能提高皮肤细胞更新的速度,使新生成的皮肤暴露在阳光下,增加晒伤和色素沉着的风险。由于局部类维生素a会使皮肤变得敏感,因此防晒霜必须具有提高皮肤弹性的进一步好处,这是传统防晒所急需的。“EI Pro视黄醇防晒霜”推出了一款新的创新防晒霜,含有紫外线防护剂和其他活性成分,具有镇静和舒缓的特性,可以最大限度地减少红斑和干燥。EI推出了“EI PRO视黄醇系列”,其中包括“EI PRO视黄醇防晒霜”,以保护皮肤免受紫外线的有害影响,以及由类视黄醇作用对皮肤造成的进一步刺激和瘙痒。在这项研究中,研究人员试图使用一种专利防晒剂(水、乙基己基甲氧基肉桂酸酯、丁基甲氧基二苯甲酰甲烷、二苯甲酮-3、磷脂和1,3-丁二醇的组合)和cruentum卟啉(海藻)来开发和设计一种防晒霜,以增强皮肤弹性,抗坏血酸等抗氧化剂,维生素E,以及胡萝卜籽油和透明质酸钠等舒缓剂。防晒霜的评估依据是防晒系数(SPF)、PA等级和临界波长。通常,SPF值在50以上,PA值++++,临界波长在370纳米以上的防晒霜可以提供更高的防晒效果,并能阻挡UVA和UVB射线。结果表明,“EI PRO视黄醇防晒霜”的临界波长为376.67,被认为是一种广谱SPF 50 PA++++防晒霜。因此,“EI PRO视黄醇防晒霜”也被证明对皮肤是安全的,没有刺激,并且通过单盲斑贴试验方法被证明是无刺激的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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