ENTIERE IDENTITIES BETWEEN OPHIOCOMINA NIGRA IGKAPPA GENE AND HUMAN IMMUNOGLOBULIN KAPPA LOCUS.NEW ASPECTS OF INVERTEBRATE IGKAPPA GENES (IPA)

Abstract

Entiere identities between Invertebrate Ophiocomina nigra IGKappa gene and Human IGK gene are confirmed, in the present work, at the level of immunoglobulin domains (constant and variable). The transcriptome of the Ophuirid : Ophiocomina nigra IGKappa gene was discovered recently(1).Since it was synthesized de novo and cloned in a pUC-GW-Kan plasmid (2) which was a gift of Bo Huang laboratories. The original sequence of the IGKappa gene, after cloning, was the following in 5’-3’ :