Case report : Use of Phototherapy for Acrodermatitis Continua of Hallopeau in Childhood: Case Report and Review of the Literature

M. Napolitano, T. Cirillo, C. Patruno, P. Gisonni, M. Megna, N. Balato
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Abstract

A 6-year-old girl presented to our attention with a 7-month history of erythema and pustules on the distal portion of her left first finger, which deeply affected the beginning of her scholar activity. On examination, her digit was swollen, markedly erythematous, and littered with several small pustules; nail was strikingly dysmorphic. The other digits showed variable degree of onychodystrophy (Fig. 1A). There were neither prior history of psoriatic lesions nor familiarity for psoriasis. Microscopic and cultural examination did not show any microbiological infection. Histological sample showed psoriasiform hyperplasia, with a collection of granulocytes in the context of parakeratosis as well as in the intraepithelial area (Munro-like microabscesses), and focal spongiosis with absent granular layer. The dermis showed increased vascularity within the dermal papillae. Ultrasonography highlighted cutaneous and sub-cutaneous thickness increase with intra-articular synovial effusion (Fig. 1C); at color Doppler, increase of vascularization was present in sub-cutaneous tissue (Fig. 1D). On the basis of these findings, a diagnosis of acrodermatitis continua of Hallopeau (ACH) was performed. Past treatment only consisted of topical steroids. A cycle of clobetasol 0.05% ointment under occlusion and narrow band UVB (310 -311 nm) was prescribed for 30 days. The improvement observed at follow-up visit (Fig. 1B), increased after the subsequent 2 months of therapy, without relapse. The young patient is still under treatment and no relapse was notead at 3.5 months follow-up.
病例报告:应用光疗治疗儿童持续肢端皮炎:病例报告及文献复习
一名6岁女孩向我们报告,她的左手食指远端有7个月的红斑和脓疱病史,这严重影响了她开始学习活动。经检查,她的手指肿胀,明显红斑,并散落着几个小脓疱;指甲明显畸形。其他手指显示不同程度的甲营养不良(图1A)。既往无银屑病病变史,也不熟悉银屑病。显微镜和培养检查未见任何微生物感染。组织学样本显示银屑病样增生,在角化不全和上皮内区域(门罗样微脓肿)中有粒细胞聚集,以及没有颗粒层的局灶性海绵状病变。真皮乳突内血管增多。超声显示皮肤和皮下厚度增加,关节内滑膜积液(图1C);彩色多普勒显示皮下组织血管化增加(图1D)。在这些发现的基础上,诊断为连续性埃洛珀肢端皮炎(ACH)。过去的治疗只包括局部类固醇。给予0.05%氯倍他索软膏一个疗程,疗程为30天,疗程为窄带UVB (310 -311 nm)。在随访中观察到的改善(图1B),在随后的2个月治疗后增加,没有复发。年轻患者仍在接受治疗,随访3.5个月未见复发。
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