Examining estradiols neuroprotective abilities and mechanisms of action in cerebrovascular accidents and neurodegenerative conditions

Abstract

Estrogens are known for playing essential roles in the body. These hormones exert crucial protective actions when faced with neural damage. Numerous studies have provided a deep understanding of these unique actions that go far beyond the scope of reproduction and reproductive regulation. Through various mechanisms, delivery routes, dosage levels, and with the age and health status of the individuals receiving the treatment in mind, the hormone can be used in protecting against neural death. This review examines the discoveries that comprise the current body of knowledge regarding estrogen as a neuro-protector against cerebrovascular accidents (CVA, stroke) and neurodegenerative diseases. These findings have great implications for improving the quality of life in the aging population. They provide insight into the impact of hormones on the protection of neural tissues, and prompt discussion between members of the scientific community, ensuring that future clinical studies utilize methods that will maximize the quality of the obtained results.