DEREGULATORY ACTION OF ENDOCRINE DISRUPTOR DDT ON MORPHOGENESIS AND FUNCTION OF ADRENAL ZONA GLOMERULOSA

Abstract

Exposure to endocrine disruptor DDT impairs development of adrenal zona glomerulosa by higher expression of pluripotency factors along with the suppression of factors that ensure the maturation of cortical cells. It leads to a decrease in aldosterone production and compensatory hyperplasia of zona glomerulosa.