P89 Vitamin D deficiency increases susceptibility to COVID-19 infection

S. Kumar, R. Ragatha, S. Waring, G. Gamtkitsulashvili, A. D'Souza, M. Mahenthiran, S. Tan, M. Parsons, S. Visuvanathan, A. Sefton, U. Ekeowa, P. Russell
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Abstract

BackgroundVitamin D plays a vital part in modulating the immune system, with Vitamin D deficiency leading to increased susceptibility to infection.1 There is some evidence to suggest Vitamin D may play a protective role in the prevention of COVID-19 infection in hospitalised patients,2 but the topic remains controversial. Our study aims to investigate if low Vitamin D levels correlate with increased risk of COVID-19 infection, thereby representing a modifiable risk factor for COVID-19 infection.MethodA retrospective observational study was conducted on 3198 health care workers of a Greater London District General Hospital, who had undergone testing for 25-OH Vitamin D levels and COVID-19 antibody in June 2020. In accordance with NICE guidelines, Vitamin D deficiency was defined as less than 25 nmol/L, insufficiency as 25–50 nmol/L, and those with levels over 50 nmol/L were used as control comparisons. Evidence of previous SARS-CoV-2 infection was assessed by detection of SARS-CoV-2 IgG antibodies. Regression analysis was performed to determine independent significance, accounting for age and gender.Results3191 participants were included in this study, with age ranging from 19–78 years (mean 42.9) of which 78.2% were female. Both age and gender were not independently associated with positive SARS-CoV-2 IgG antibodies. 1997 (62.6%) participants had Vitamin D levels within the normal range, 899 (28.2%) participants had insufficient levels and 302 (9.4%) had Vitamin D deficiency. Both Vitamin D deficiency (OR 1.61, p=0.002) and insufficiency (OR 1.33, p=0.006) independently correlated with significantly increased incidence of positive COVID-19 antibodies than personnel with normal Vitamin D levels.ConclusionsWe report the largest single-centre study investigating the impact of low Vitamin D levels within healthcare workers to date. Significant correlation between low levels of Vitamin D and previous COVID-19 infection was identified. Oral Vitamin D supplementation to maintain levels >50 nmol/L may play a protective role against COVID-19. Larger studies are needed to investigate the role of Vitamin D supplementation in healthcare workers for further COVID-19 waves.ReferencesAranow C, et al. Journal of Investigative Medicine 2011;59:881–886.Nogues X, et al. J Clin Endocrinol Metab. 2021 Jun 7:dgab405.
P89缺乏维生素D会增加COVID-19感染的易感性
维生素D在调节免疫系统中起着至关重要的作用,缺乏维生素D会导致对感染的易感性增加有证据表明,维生素D可能在预防住院患者感染COVID-19方面发挥保护作用,但这个话题仍然存在争议。我们的研究旨在调查低维生素D水平是否与COVID-19感染风险增加相关,从而代表COVID-19感染的可改变危险因素。方法对2020年6月接受25-OH维生素D水平和COVID-19抗体检测的大伦敦地区总医院3198名医护人员进行回顾性观察研究。根据NICE指南,维生素D缺乏被定义为低于25 nmol/L,不足被定义为25 - 50 nmol/L,而水平超过50 nmol/L的人被用作对照。通过检测SARS-CoV-2 IgG抗体评估既往SARS-CoV-2感染的证据。考虑到年龄和性别,进行回归分析以确定独立显著性。结果共纳入3191例受试者,年龄19 ~ 78岁,平均42.9岁,其中78.2%为女性。年龄和性别与SARS-CoV-2 IgG抗体阳性无独立相关性。1997名(62.6%)参与者的维生素D水平在正常范围内,899名(28.2%)参与者维生素D水平不足,302名(9.4%)参与者维生素D缺乏。与维生素D水平正常的人员相比,维生素D缺乏(OR 1.61, p=0.002)和维生素D不足(OR 1.33, p=0.006)与COVID-19抗体阳性发生率显著增加独立相关。结论:我们报告了迄今为止最大的单中心研究,调查了低维生素D水平对医护人员的影响。发现维生素D水平低与先前的COVID-19感染之间存在显著相关性。口服维生素D维持在>50 nmol/L水平可能对COVID-19起保护作用。需要进行更大规模的研究,以调查补充维生素D在医护人员中对进一步的COVID-19浪潮的作用。参考文献aranow C等。调查医学杂志2011;59:881-886。Nogues X,等。临床内分泌杂志。2021年6月7日:dgab405。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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