Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphism and the risk of diabetic nephropathy in type 2 diabetes..

Abstract

Diabetic Nephropathy (DN) poses a major health problem. There is strong evidence for a potential role of the eNOS gene. The aim of this case control study was to investigate the possible role of genetic variants of the endothelial Nitric Oxide Synthase (eNOS) gene(VNTR) in the pathogenesis of nephropathy in patients with diabetes mellitus. The study included 196 subjects (145 T2DM and 51 normal control)  T2DM were classified into 2 groups:  97 diagnosed with DN, and 48  diabetic without nephropathy and hypertension as   +ve control. randomly selected was conducted to assess the association of SNP eNOSintron 4a/b VNTR polymorphism gene with diabetic nephropathy in Iraqi population. Blood samples from subjects and controls were analyzed to investigate the eNOS genotypesNo significant differences were found in the frequency of eNOS genotypes between diabetic patients (either in group 1 or group 2) and controls (p >0.05). Also, no significant differences were found in the frequency of eNOS genotypes between group 1 and group 2 (p >0.05).