Association between Platelet/Lymphocyte Ratio and Angiographic No-Reflow in Patients with None-St Segment Elevation Acute Myocardial Infarction Undergoing Primary Coronary Intervention

Abstract

Introduction: Inflammation and platelet activation play a central role in the initiation and progression of the atherosclerosis process. The Platelet-to-lymphocyte ratio (PLR) is a new prognostic marker in coronary artery disease. The PLR is a significant independent predictor of longterm mortality after none-ST elevated myocardial infarction (NSTEMI). We aimed to evaluate the relationship between PLR and no-reflow (NR) in patients with NSTEMI. Material and methods: The present study included 173 patients with NSTEMI. The patients were classified into two groups as follows: 115 patients in the NR group and 58 patients in the normal reflow group. NR was defined as coronary thrombolysis in myocardial infarction (TIMI) flow grade ≤ 2 after vessel recanalization with primary percutaneous coronary intervention. The PLR was calculated from the complete blood count. Results: The PLR values of the patients with NR were significantly higher than those of patients with normal reflow (108.6 (14.6-511.3) vs. 91.7 (17.2-225.3), p = 0.01). Also, neutrophil-to-lymphocyte ratio (NLR) was significantly higher in the NR group than the normal-reflow group (3.0 (0.316.5) vs. 2.3 (0.01-12.5), p = 0.02). The Correlation between the PLR and NLR was positive and significant (r = 0.68, p < 0.001). Conclusion: This study showed that PLR is an independent predictor of NR in patients with NSTEMI.