Ellipsometer surface plasma resonance

Abstract

In this dissertation, a multi-functional optical biochip system was presented. This biosensor is developed by integrating ellipsometry and SPR detection techniques, which adopted a paraboloidal mirror and a spherical mirror to vary the incident angle, a LCD phase modulator to control incident light beam retardance, a reference optical path to calculate the phase modulated by LCD, and a flow-injection system to drive bio-samples to biochip. The other important function of this biosensor is to observe SPR phenomenon by using the ellipsometric configuration. By using this method, the SPR resolution could be significantly enhanced, and the characteristics of ellipsometry give detailed information for bio-tech analysis. Information such as film thickness, physical parameters, concentration, mass, density, kinetic constants, binding specificity, etc. can all be retrieved. This biosensor was named ESPR which is an acronym of Ellipsometry-SPR. In summary, ESPR could serve both as a research and development tool as well as a manufacturing tool in biomedical area.