Pulmonary Function Tests Abnormalities In Parkinson Disease

H. Mikaelee, M. Yazdchi, K. Ansarin, M. Arami
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引用次数: 11

Abstract

Objective: In patients with Parkinson's disease (PD) and other extrapyramdial disorders, respiratory problems commonly contribute to morbidity and mortality. The aim of this study is to investigate the characteristics of pulmonary function tests (PFT) abnormalities in patients with PD. Materials and Methods: PFTs performed in 25 patients suffered PD (19 male 69%, 6 Female 24 % ) without known respiratory and cardiovascular disease and no history of smoking and 25 healthy individuals as an age and sex matched control group. We obtained Body plethysmographic measurements of lung volumes and respiratory determinations of PFT. PD severity was evaluated by Hoehn and Yahr staging. Results: The mean age of PD onset was 58.8±11.6 years. 44 % (n= 4) of patients in H-Y Group 1, and 75 % (n= 6) in group 2 and 3 and 75% (n=6) in group 4 and 5 had abnormal PFT values. Between various tests, the Residual Volume (RV>120 % of normal value); Forced Vital Capacity (FVC<80 % of normal value) and FEV1 / FVC Ratio<75 % of normal ratio, were significantly abnormal in patients with PD compared with the controls, (p<0.05). Also obstructive pulmonary function disorders were significantly common in patients, (p<0.04). Conclusions: Obstructive pattern of respiratory abnormalities is the most common type of PFT impairment in PD patients. The evaluation and rehabilitation of pulmonary disorders should be routinely included in the management of PD patients. This study has supported by Research Assistance of Tabriz University of Medical Sciences
帕金森病肺功能检查异常
目的:在帕金森病(PD)和其他锥体外系疾病患者中,呼吸问题通常是导致发病率和死亡率的重要因素。本研究的目的是探讨PD患者肺功能检查(PFT)异常的特点。材料和方法:25例无呼吸和心血管疾病、无吸烟史的PD患者(19例男性69%,6例女性24%)和25例年龄和性别匹配的健康人作为对照组。我们获得了肺体积的体体积描记仪测量和PFT的呼吸测定。采用Hoehn和Yahr分期评估PD严重程度。结果:PD患者平均发病年龄为58.8±11.6岁。H-Y组1 44% (n= 4), 2、3组75% (n=6), 4、5组75% (n=6) PFT值异常。各试验之间的残余体积(RV>正常值的120%);PD患者用力肺活量(FVC<正常值的80%)和FEV1 / FVC比值<正常值的75%,与对照组比较差异有统计学意义(p<0.05)。阻塞性肺功能障碍在患者中也很常见(p<0.04)。结论:阻塞性呼吸异常是PD患者最常见的PFT损害类型。肺疾病的评估和康复应常规纳入PD患者的管理。这项研究得到了大不里士医科大学研究援助的支持
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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